Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/9142
Type: Artigo de periódico
Title: Flavonoids from Lonchocarpus muehlbergianus
Author: Magalhães, Aderbal F.
Tozzi, Ana M.G.A.
Magalhães, Eva G.
Blanco, Ivani S.
Soriano, Maria-Del-Pilar C.
Abstract: The light petroleum extract from the roots of Lonchocarpus muehlbergianus Hassl contained nine flavonoids, including six new ones. These are 2,4-cis-2,4,5,8-tetramethoxy-(2´´,3´´:6,7)-furanoflavan; 2,4-cis-4-hydroxy-2,5,8-trimethoxy-(2´´,3´´:6,7)-furanoflavan; 2,4-cis-2-prenyloxy-4,5,8-trimethoxy-(2´´,3´´:6,7)-fu-ranoflavan; 2,4-cis-2-prenyloxy-4-hydroxy-5,8-dimethoxy-(2´´,3´´:6,7)-furanoflavan; 2',5',6'-trimethoxy-9-(1,1-dimethylallyoxy)-[2´´,3´´:3´,4´]-furanochalcone; 5,6-dimethoxy-(2´´,3´´:7,8)-furanoflavone, identi-fied by analysis of their spectral data (UV, IR, ¹H and 13C NMR, 2D-NMR, NOE and MS). The natural occurrence of 2,4-dioxygenated flavan derivatives is being reported for the first time. Quantitative analysis of the petrol extract, by using reversed-phase HPLC, showed that the most abundant flavonoid in the extract is 2,4-cis-2,4,5,8- tetramethoxy-(2´´,3´´:6,7)-furanoflavan.
O extrato éter de petróleo das raízes de Lonchocarpus muehlbergianus foi submetido a sucessivas análises cromatográficas (CC, CCD e CDC preparativa) levando ao isolamento de nove flavonóides (1-9) dos quais seis são inéditos na literatura (1-6) destacando-se as quatro flavanas 2,4-dioxigenadas (1-4) que representam uma nova classe de flavonóides. As estruturas moleculares foram determinadas através da análise dos respectivos espectros de RMN ¹H, RMN 13C e DEPT, RMN-2D (COSY, HETCOR e COLOC), NOE, IV, UV e EM. A análise quantitativa por CLAE, mostrou que a nova flavana 1 é o flavonóide que ocorre em maior abundância no extrato.
Subject: Lonchocarpus muehlbergianus
Leguminosae
flavonóides
flavanas
Lonchocarpus muehlbergianus
Leguminosae
flavonoids
flavans
Editor: Academia Brasileira de Ciências
Rights: aberto
Identifier DOI: 10.1590/S0001-37652004000400004
Address: http://dx.doi.org/10.1590/S0001-37652004000400004
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652004000400004
Date Issue: 1-Dec-2004
Appears in Collections:Unicamp - Artigos e Outros Documentos

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