Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/91336
Type: Artigo de periódico
Title: Expression Of Class I Major Histocompatibility Complex (mhc I) In The Central Nervous System: Role In Synaptic Plasticity And Regeneration [expressão Do Complexo De Histocompatilidade Principal De Classe I (mhc I) No Sistema Nervoso Central: Plasticidade Sináptica E Regeneração]
Author: Zanon R.G.
Emirandetti A.
Ferreira Simoes G.
Marques Freria C.
Cristina Victorio S.
Politti Cartarozzi L.
Barbizan R.
Rodrigues De Oliveira A.L.
Abstract: It has been recently demonstrated that the major histocompatibility complex of class I (MHC I) expressed in the central nervous system (CNS) does not only function as a molecule of the immune system, but also plays a role in the synaptic plasticity. The expression of MHC I influences the intensity and selectivity of elimination of synapses apposed to neurons that were subjected to lesion, besides influencing the reactivity of neighboring glial cells. MHC I expression and the degree of synaptic rearrangement and glial response after injury correlate with differences in the regenerative potential and functional recovery of isogenic mice strains. In this way, the new aspects regarding MHC I functions in the CNS may guide further studies aiming at searching the involvement of MCH I in neurologic disorders, as well as the development of new therapeutic strategies.
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Rights: aberto
Identifier DOI: 
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957113168&partnerID=40&md5=e666bc4b5b346f56b217ef9336e62db0
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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