Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/91220
Type: Artigo de periódico
Title: Biotransformation Of α-bromoacetophenones By The Marine Fungus Aspergillus Sydowii
Author: Rocha L.C.
Ferreira H.V.
Pimenta E.F.
Berlinck R.G.S.
Rezende M.O.O.
Landgraf M.D.
Seleghim M.H.R.
Sette L.D.
Porto A.L.M.
Abstract: The biotransformation reactions of α-bromoacetophenone (1), p-bromo-α-bromoacetophenone (2), and p-nitro-α-bromoacetophenone (3) by whole cells of the marine fungus Aspergillus sydowii Ce19 have been investigated. Fungal cells that had been grown in artificial sea water medium containing a high concentration of chloride ions (1.20 M) catalysed the biotransformation of 1 to 2-bromo-1-phenylethanol 4 (56%), together with the α-chlorohydrin 7 (9%), 1-phenylethan-1,2-diol 9 (26%), acetophenone 10 (4%) and phenylethanol 11 (5%) identified by GC-MS analysis. In addition, it was observed that the enzymatic reaction was accompanied by the spontaneous debromination of 1 to yield α-chloroacetophenone 5 (9%) and α-hydroxyacetophenone 6 (18%) identified by GC-FID analysis. When 2 and 3 were employed as substrates, various biotransformation products were detected but the formation of halohydrins was not observed. It is concluded that marine fungus A. sydowii Ce19 presents potential for the biotransformations of bromoacetophenone derivatives. © 2009 Springer Science+Business Media, LLC.
Editor: 
Rights: fechado
Identifier DOI: 10.1007/s10126-009-9241-y
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77957755661&partnerID=40&md5=57289003a101de3740bb155894df1540
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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