Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/91114
Type: Artigo de periódico
Title: Synthesis, Antiproliferative Activity In Cancer Cells And Theoretical Studies Of Novel 6α,7β-dihydroxyvouacapan-17β-oic Acid Mannich Base Derivatives
Author: Euzebio F.P.G.
Santos F.J.L.D.
Pilo-Veloso D.
Alcantara A.F.C.
Ruiz A.L.T.G.
Carvalho J.E.D.
Foglio M.A.
Ferreira-Alves D.L.
Fatima A.D.
Abstract: Natural products are great prototypes for the design of new anticancer agents. The plant-derived natural product 6α,7β-dihydroxyvouacapan- 17β-oic acid (1) is promising for the development of more potent antiproliferative agents against human cancer cells. Indeed, its lactone derivative 6α-hydroxyvouacapan-7β,17β-lactone (2), a non-natural furanoditerpene, exhibited higher anticancer activity than compound 1. Herein, we describe the synthesis and antiproliferative activity of six new Mannich derivatives of compound 2 against nine cancer cell lines. Overall, our results revealed that Mannich derivatives 3-8 were more potent than compound 2 in inhibiting the proliferation of cancer cells. Theoretical studies also supported our findings, revealing the nucleophilic character of furan ring as an important feature for antiproliferative activity of the studied Mannich derivatives. © 2010 Elsevier Ltd. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2010.10.015
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-78249252665&partnerID=40&md5=ed0a2bf6e617f422bd1929877a72bba5
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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