Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/91060
Type: Artigo de periódico
Title: Uvb: Susceptibility As A Risk Factor To The Development Of Lepromatous Leprosy [uvb Suscetibilidade Como Fator De Risco Para O Desenvolvimento Da Hanseníase Virchowiana]
Author: Rodrigues M.M.
Ximenes R.A.D.A.
Dantas M.M.D.S.
Batista T.D.
Freire A.D.L.
Abstract: Backgrounds - Ultraviolet radiation B (UVRB) is the most important environmental factor capable of altering the immune function of human skin. Objective: To evaluate the association of the phenotypes of susceptibility or resistance to ultraviolet radiation B (UVRB) and the polar forms of leprosy. Material and methods: We evaluated 38 patients with lepromatous leprosy (LL) and 87 patients with tuberculoid (TT) leprosy, according to the classification by Ridley and Jopling (1966). All the patients were submitted to a test to determine the phenotypes of susceptibility or resistance to UVRB through the application of a 2% dinitrochlorobenzene (DNCB) disc to a previously irradiated area with twice the minimal erythema dose (MED). After 21 days, a similar disc soaked in 0.05% DNCB was applied to the scapular area (unexposed to UVRB) to check for sensitiveness, with reading of the results after 48 hours. The patients that showed a positive reaction to DNCB were considered resistant (UVB-R) and those who did not show any reaction were considered susceptible (UVB-S). Results: The frequency of UVB-S individuals was 63.2% (24 patients) in the LL group and 34.4% (30 patients) in the TT group (OR=3.26; IC=1.36 - 7.87; x2=7.73; p=0.005). Conclusion: Our results suggest that UVB-susceptibility is a risk factor to the development of lepromatous leprosy (LL). ©2010 by Anais Brasileiros de Dermatologia.
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Rights: aberto
Identifier DOI: 10.1590/S0365-05962010000600009
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-79951630077&partnerID=40&md5=c2113ae28803248dd0680f9dd3b8bd8b
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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