Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/91047
Type: Artigo de periódico
Title: Central Leptin Action Improves Skeletal Muscle Akt, Ampk, And Pgc1α Activation By Hypothalamic Pi3k-dependent Mechanism
Author: Roman E.A.F.R.
Reis D.
Romanatto T.
Maimoni D.
Ferreira E.A.
Santos G.A.
Torsoni A.S.
Velloso L.A.
Torsoni M.A.
Abstract: Central leptin action requires PI3K activity to modulate glucose homeostasis and peripheral metabolism. However, the mechanism behind this phenomenon is not clearly understood. We hypothesize that hypothalamic PI3K activity is important for the modulation of the AMP-activated protein kinase (AMPK)/acetyl-CoA carboxylase (ACC) pathway, PGC1α, and AKT in skeletal muscle (SM). To address this issue, we injected leptin into the lateral ventricle of rats. Hypothalamic JAK2 and AKT were activated by intracerebroventricular (ICV) injection of leptin in a time-dependent manner. Central leptin improved tolerance to glucose (GTT), increased PGC1α expression, and AKT, AMPK, ACC and JAK2 phosphorylation in the soleus muscle. Previous ICV administration of either LY294002 or propranolol (IP) blocked these effects. We concluded that the activation of the hypothalamic PI3K pathway is important for leptin-induced AKT phosphorylation, as well as for active catabolic pathway through AMPK and PGC1α in SM. Thus, a defective leptin signalling PI3K pathway in the hypothalamus may contribute to peripheral resistance to insulin associated to diet-induced obesity. © 2009 Elsevier Ireland Ltd. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.mce.2009.08.007
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-70350203976&partnerID=40&md5=05e2d34ae431af86e3ee1b68094b987a
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-70350203976.pdf859.93 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.