Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/90999
Type: Artigo de periódico
Title: Modulation Of Hypothalamic Ptp1b In The Tnf-α-induced Insulin And Leptin Resistance
Author: Picardi P.K.
Caricilli A.M.
Abreu L.L.F.D.
Carvalheira J.B.C.
Velloso L.A.
Saad M.J.A.
Abstract: We have associated functional and molecular studies of insulin and leptin to investigate the effect of TNF-α on central insulin and leptin signaling in rats pre-treated with PTP1B-ASO. The icv infusion of TNF-α-induced an increase in PTP1B protein expression and activity, and attenuated insulin and leptin sensitivity and signaling in the hypothalamus. However, TNF-α was able to completely blunt the leptin and insulin effect in rats treated with PTP1B-ASO, suggesting that TNF-α does not require PTP1B to fully attenuate the leptin and insulin effects. In addition, our data also show that other mechanisms of insulin and leptin resistance are activated in the hypothalamus by TNF-α. © 2010 Federation of European Biochemical Societies.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.febslet.2010.05.064
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77954175048&partnerID=40&md5=2989a3470d4622052558085a8ff2feb9
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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