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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleHypoxia, Hypoxia-inducible Factor-1α And Vascular Endothelial Growth Factor In A Murine Model Of Schistosoma Mansoni Infectionpt_BR
dc.contributor.authorAraujo A.P.pt_BR
dc.contributor.authorFrezza T.F.pt_BR
dc.contributor.authorAllegretti S.M.pt_BR
dc.contributor.authorGiorgio S.pt_BR
unicamp.authorAraújo, A.P., Department of Animal Biology, Biology Institute, Universidade Estadual de Campinas, Caixa Postal 6109, Cep 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorFrezza, T.F., Department of Animal Biology, Biology Institute, Universidade Estadual de Campinas, Caixa Postal 6109, Cep 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorAllegretti, S.M., Department of Animal Biology, Biology Institute, Universidade Estadual de Campinas, Caixa Postal 6109, Cep 13083-970, Campinas, SP, Brazilpt_BR
unicamp.authorGiorgio, S., Department of Animal Biology, Biology Institute, Universidade Estadual de Campinas, Caixa Postal 6109, Cep 13083-970, Campinas, SP, Brazilpt_BR
dc.description.abstractSchistosomiasis mansoni is a chronic parasitic disease where much of the symptomatology is attributed to granuloma formation, an immunopathological reaction against Schistosoma eggs. To more clearly understand the immunopathology of schistosomiasis, the tissue microenvironment generated by S. mansoni infected mice was investigated. Using the hypoxia marker pimonidazole, we provide immunohistochemical evidence that hypoxia occurred in inflammatory cells infiltrated around the eggs and cells surrounding granulomas in the liver, intestine, spleen and lungs of infected mice. Hypoxia-inducible factor-1α (HIF-1α) was mainly expressed in inflammatory cells surrounding the eggs and in hepatocytes surrounding cellular and fibrocellular granulomas in infected mouse liver. HIF-1α expression was also verified in granulomas in the other tissues tested (intestine, spleen and lungs). Vascular endothelial growth factor (VEGF) expression was observed in the extracellular space surrounding inflammatory cells in liver granuloma. The VEGF expression pattern verified in infected mouse liver was very similar to that observed in the other tissues tested. A strong positive correlation occurred between pimonidazole binding and HIF-1α and VEGF expression in the tissues tested, except for lung. This work is the first evidence that infection by a helminth parasite, S. mansoni, produces a hypoxic tissue microenvironment and induces HIF-1α and VEGF expression. © 2010 Elsevier Inc.en
dc.relation.ispartofExperimental and Molecular Pathologypt_BR
dc.date.issued2010pt_BR
dc.identifier.citationExperimental And Molecular Pathology. , v. 89, n. 3, p. 327 - 333, 2010.pt_BR
dc.language.isoenpt_BR
dc.description.volume89pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage327pt_BR
dc.description.lastpage333pt_BR
dc.rightsfechadopt_BR
dc.sourceScopuspt_BR
dc.identifier.issn144800pt_BR
dc.identifier.doi10.1016/j.yexmp.2010.09.003pt_BR
dc.identifier.urlhttp://www.scopus.com/inward/record.url?eid=2-s2.0-78249235607&partnerID=40&md5=76ad6055c5e7ee11e9a5537df0e9d600pt_BR
dc.date.available2015-06-26T12:35:44Z
dc.date.available2015-11-26T15:25:48Z-
dc.date.accessioned2015-06-26T12:35:44Z
dc.date.accessioned2015-11-26T15:25:48Z-
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dc.description.provenanceMade available in DSpace on 2015-11-26T15:25:48Z (GMT). No. of bitstreams: 2 2-s2.0-78249235607.pdf: 2832909 bytes, checksum: c6f7dc925f68a22bbe2922dc2350ee41 (MD5) 2-s2.0-78249235607.pdf.txt: 39171 bytes, checksum: 7a9f2c89a2357931d93894ae9bee0f65 (MD5) Previous issue date: 2010en
dc.identifier.urihttp://www.repositorio.unicamp.br/handle/REPOSIP/90988
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/90988-
dc.identifier.idScopus2-s2.0-78249235607pt_BR
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