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|Type:||Artigo de periódico|
|Title:||Synthesis, Antitumor And Antimicrobial Activity Of Novel 1-substituted Phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] β-carboline Derivatives|
De Carvalho J.E.
Dias Filhoc B.P.
|Abstract:||With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized β-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (% ABS) data. © 2010 Sociedade Brasileira de Química.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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