Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/90960
Type: Artigo de periódico
Title: Synthesis, Antitumor And Antimicrobial Activity Of Novel 1-substituted Phenyl-3-[3-alkylamino(methyl)-2-thioxo-1,3,4-oxadiazol-5-yl] β-carboline Derivatives
Author: Savariz F.C.
Formagio A.S.N.
Barbosa V.A.
Foglio M.A.
De Carvalho J.E.
Duarte M.C.T.
Dias Filhoc B.P.
Sarragiotto M.H.
Abstract: With the purpose of activity enhancement of 1-substituted phenyl-3-(2-thioxo-1,3,4-oxadiazol-5-yl) β-carbolines 1a-c, reported as potential antitumor agents in our previous study, herein we report the synthesis and antitumor activity evaluation of several novel Mannich bases 2-7(a-c), by the introduction of different alkylamino(methyl) groups in the 1,3,4-oxadiazole unity of 1a-c. The antimicrobial activities of 1a-c and of 2-7(a-c) were also evaluated. Additionally, an in silico study of the ADME properties of novel synthesized β-carboline derivatives 2-7(a-c) was performed by evaluation of their Lipinski's parameters and topological polar surface area (TPSA) and percentage of absorption (% ABS) data. © 2010 Sociedade Brasileira de Química.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77951832636&partnerID=40&md5=dddfb5498d01130ec135e07c9f463007
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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