Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Cytochalasins Produced By Xylaria Sp., An Endophytic Fungus From Piper Aduncum [citocalasinas Produzidas Por Xylaria Sp., Um Fungo Endofítico De Piper Aduncum (piperaceae)]
Author: Silva G.H.
De Oliveira C.M.
Teles H.L.
Da S. Bolzani V.
Araujo A.R.
Pfenning L.H.
Young M.C.M.
Costa-Neto C.M.
Haddad R.
Eberlin M.N.
Abstract: A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
Rights: aberto
Identifier DOI: 
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-78650585353.pdf194.32 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.