Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/90833
Type: Artigo de periódico
Title: Cytochalasins Produced By Xylaria Sp., An Endophytic Fungus From Piper Aduncum [citocalasinas Produzidas Por Xylaria Sp., Um Fungo Endofítico De Piper Aduncum (piperaceae)]
Author: Silva G.H.
De Oliveira C.M.
Teles H.L.
Da S. Bolzani V.
Araujo A.R.
Pfenning L.H.
Young M.C.M.
Costa-Neto C.M.
Haddad R.
Eberlin M.N.
Abstract: A chemical study on the EtOAc extract produced by Xylaria sp., an endophytic fungus from Piper aduncum, resulted in the isolation of a new cytochalasin 1, along with five known 19,20-epoxycytochalasin D (2), C (3), N (4), Q (5), and R (6). The 1-6 were evaluated against the fungi C. cladosporioides and C. sphaerospermum and only 5 showed weak activity. The cytotoxicity in vitro against HeLA and CHO cells lines were investigated and the cytochalasins 2-4, and 6 showed a strong activity against HeLA. The DNAdamaging activity of 1-6 were also investigated against mutant strains of S. cerevisiae.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-78650585353&partnerID=40&md5=58b362f9d465fb404dcf45b04734183d
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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