Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/90817
Type: Artigo de periódico
Title: Development And Characterization Of Poli (l-lactide) Nanocapsules Containing Benzocaine [desenvolvimento E Caracterização De Nanocápsulas De Poli (l-lactídeo) Contendo Benzocaína]
Author: De Melo N.F.S.
Grillo R.
Rosa A.H.
Fraceto L.F.
Filho N.L.D.
De Paula E.
De Araujo D.R.
Abstract: In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-77949373115&partnerID=40&md5=0de7fd45f2221c3a39f18c62dc70e9a7
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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