Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Development And Characterization Of Poli (l-lactide) Nanocapsules Containing Benzocaine [desenvolvimento E Caracterização De Nanocápsulas De Poli (l-lactídeo) Contendo Benzocaína]|
|Author:||De Melo N.F.S.|
De Paula E.
De Araujo D.R.
|Abstract:||In this paper we describe the preparation poly (L-lactide) (PLA) nanocapsules as a drug delivery system for the local anesthetic benzocaine. The characterization and in vitro release properties of the system were investigated. The characterization results showed a polydispersity index of 0.14, an average diameter of 190.1± 3 nm, zeta potential of -38.5 mV and an entrapment efficiency of 73%. The release profile of Benzocaine loaded in PLA nanocapsules showed a significant different behavior than that of the pure anesthetic in solution. This study is important to characterize a drug release system using benzocaine for application in pain treatment.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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