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Type: Artigo de periódico
Title: Up-regulation Of 14-3-3σ (stratifin) Is Associated With High-grade Cin And High-risk Human Papillomavirus (hpv) At Baseline But Does Not Predict Outcomes Of Hr-hpv Infections Or Incident Cin In The Lams* Study
Author: Syrjanen S.
Naud P.
Sarian L.
Derchain S.
Roteli-Martins C.
Longatto-Filho A.
Tatti S.
Branca M.
Erzen M.
Hammes L.S.
Costa S.
Syrjanen K.
Abstract: To assess whether the potentially high-risk (HR) human papillomavirus (HPV)-related up-regulation of 14-3-3σ (stratifin) has implications in the outcome of HPV infections or cervical intraepithelial neoplasia (CIN) lesions, cervical biopsy specimens from 225 women in the Latin American Screening Study were analyzed for 14-3-3σ expression using immunohistochemical analysis. We assessed its associations with CIN grade and HR HPV at baseline and value in predicting outcomes of HR-HPV infections and the development of incident CIN 1+ and CIN 2+. Expression of 14-3-3σ increased in parallel with the lesion grade. Up-regulation was also significantly related to HR-HPV detection (P = .004; odds ratio, 2.71; 95% confidence interval, 1.37-5.35) and showed a linear relationship to HR-HPV loads (P = .003). 14-3-3σ expression was of no value in predicting the outcomes (incident, persistent, clearance) of HR-HPV infections or incident CIN 1+ and CIN 2+. 14-3-3σ is not inactivated in cervical carcinoma and CIN but is up-regulated on transition from CIN 2 to CIN 3. Its normal functions in controlling G1/S and G2/M checkpoints are being bypassed by HR HPV. © American Society for Clinical Pathology.
Rights: fechado
Identifier DOI: 10.1309/AJCP49DOITYDCTQJ
Date Issue: 2010
Appears in Collections:Unicamp - Artigos e Outros Documentos

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