Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/90242
Type: Artigo de periódico
Title: Effect Of Dexamethasone And Ketoprofen On Osteogenesis And Bone Resistance In Rats [efeito Da Dexametasona E Do Cetoprofeno Na Osteogênese E Na Resistência óssea Em Ratos]
Author: da Silva P.C.S.
Camilli J.A.
Nakagaki W.R.
Soares E.A.
Garcia J.A.D.
Abstract: This study aimed at evaluating the effect of ketoprofen (NSAID) and dexamethasone (SAID) on osteogenesis around a dense hydroxyapatite (DHA) implant in the tibia and parietal bone, and on the bone resistance. Fifteen fifty-day-old Wistar rats weighing on average 250±30 g were used. The animals were separated into three groups (n=5): control (CT); non-steroidal anti-inflammatoryl (NSAID); and steroidal anti-inflammatory (SAID). After anesthesia with IM ketamine/xylazine, a 3 mm cavity was made in the left parietal bone and in the proximal epiphysis of the left tibia. A DHA bioceramic was implanted in the tibia. The animals were treated subcutaneously during 30 days as follows: NSAID group: ketoprofen at the dose of 12/Kg/day; SAID group: dexamethasone, 0,10 mg/kg/day. The CT group received saline through the same route. All the animals received the same solid diet and water ad libitum. After 30 days of experiment, the animals wereeuthanized, and their femurs collected for the mechanical test, while their tibia and parietal sites were prepared for the histomorphometrical analysis. Microscopically, the SAID and NSAID groups showed a lower volume of neoformed bone. In addition, the NSAID and SAID group femurs required lower maximum force for complete rupture when compared with the CT group. It was concluded that ketoprofen and dexamethasone interfered with osteogenesis and decreased bone resistance by altering the bone tissue metabolism, mainly by inhibiting the COX-2 and decreasing prostaglandins. Therefore, the use of ketoprofen and dexamethasone after bone surgeries can compromise the stability and maintenance of implants.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84868153453&partnerID=40&md5=a9a5eb1b1d574ecd7d81d8febc06b848
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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