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|Type:||Artigo de periódico|
|Title:||Association Between The Ivs4g>t Mutation In The Tcf7l2 Gene And Susceptibility To Diabetes In Cystic Fibrosis Patients|
|Abstract:||Background: Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF. Findings. We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients. Conclusions: In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes. © 2012 Furgeri et al.; licensee BioMed Central Ltd.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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