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Type: Artigo de periódico
Title: Twist And P-akt Immunoexpression In Normal Oral Epithelium, Oral Dysplasia And In Oral Squamous Cell Carcinoma
Author: de Freitas Silva B.-S.
Yamamoto F.-P.
Pontes F.-S-C.
Cury S.E.-V.
Fonseca F.-P.
Pontes H.A.-R.
Decio-dos Santos P.-J.
Abstract: Objectives: The aim of this study was to evaluate the immunoexpression of TWIST and p-Akt proteins in oral leukoplakia (OL) and oral squamous cell carcinoma (OSCC), correlating their expressions with the histological features of the lesions. Study design: Immunohistochemical studies were carried out on 10 normal oral epithelium, 30 OL and 20 OSCC formalin-fixed, paraffin-embedded tissue samples. Immunoperoxidase reactions for TWIST and p-Akt proteins were applied on the specimens and the positivity of the reactions was calculated for 1000 epithelial cells. Results: Kruskal-Wallis and Dunn's post tests revealed a significant difference in TWIST and p-Akt immunoexpression among normal oral mucosa, OL and OSCC. In addition, a significant positive correlation was found between TWIST and p-Akt expressions according to the Pearson's correlation test. Conclusions: The results obtained in the current study suggest that TWIST and p-Akt may participate of the multi-step process of oral carcinogenesis since its early stages. © Medicina Oral S. L.
Rights: aberto
Identifier DOI: 10.4317/medoral.17344
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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