Please use this identifier to cite or link to this item:
Type: Artigo de periódico
Title: Gene Expression Profiling In Genetic Animal Models Of Provide Elements To Unveil The Molecular Mechanisms Underlying Epileptogenesis In Rodents [a Caracterização Do Perfil De Expressão Gênica Em Larga Escala Em Modelos Genéticos De Epilepsia Fornece Elementos Para Entender Os Mecanismos Envolvidos Na Epileptogênese Em Roedores]
Author: Matos A.H.B.
Pascoal V.D.B.
Nascimento D.R.
Martins S.
Rocha C.S.
Vasconcellos J.F.
Chamma M.T.
Maurer-Morelli C.V.
Martins A.S.
Valle A.C.
Godard A.L.B.
Lopes Cendes I.
Abstract: Objective: The objective of this study was to characterize and compare the genetic profile of two rodent models of epilepsy (Wistar Audiogenic Rat - WAR and rats with generalized epilepsy with absence seizures-GEAS) using gene expression analysis Methods: We used microarray technology for gene expression analysis. Results: The analysis of gene expression profiles in WAR showed among genes up-regulated Neurod1, involved in the development of the cochlear duct. In addition, we found significant differences in gene expression of Apbb1, Foxg1 and Scn1A. GEAS rats had differentially expressed genes related to the development of central nervous system, as well as genes involved in the MAPK pathway, transcription factors, neuronal migration and apoptosis. Conclusion: This study may help to clarify the underlying molecular mechanism that leads to the predisposition to seizures in these animals. Our results indicate the activation of distinct molecular pathways in both models.
Rights: aberto
Identifier DOI: 10.1590/S1676-26492012000200006
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84872563714.pdf111.69 kBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.