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Type: Artigo de periódico
Title: Coumarins From Free Ortho -hydroxy Cinnamates By Heck-matsuda Arylations: A Scalable Total Synthesis Of (r)-tolterodine
Author: Barancelli D.A.
Salles A.G.
Taylor J.G.
Correia C.R.D.
Abstract: Free ortho-hydroxy cinnamate ester derivatives are evaluated in the synthesis of structurally diverse 4-aryl-coumarins via a tandem Heck-Matsuda cyclization reaction. Free phenolic groups were considered incompatible with such a reaction, which usually provide the corresponding diazo dyes. A concise and scalable route employing a ligand-free, Pd-catalyzed Heck-Matsuda arylation under aerobic conditions for the preparation of (R)-Tolterodine in high overall yield and ee is also presented. © 2012 American Chemical Society.
Rights: fechado
Identifier DOI: 10.1021/ol302923f
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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