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Type: Artigo de periódico
Title: Paraganglioma Of Seminal Vesicle And Chromophobe Renal Cell Carcinoma: A Case Report And Literature Review [paraganglioma Da Vesícula Seminal E Carcinoma De Células Renais Cromófobo: Um Relato De Caso E Revisão Da Literature]
Author: Alvarenga C.A.
Lopes J.M.
Vinagre J.
Paravidino P.I.
Alvarenga M.
Prando A.
Castilho L.N.
Soares P.
Billis A.
Abstract: CONTEXT: Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina. CASE REPORT: This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors. CONCLUSIONS: No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
Rights: aberto
Identifier DOI: 10.1590/S1516-31802012000100010
Date Issue: 2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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