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Type: Artigo de periódico
Title: Tyrosine Kinase Inhibitors As Novel Drugs For The Treatment Of Diabetes
Author: Prada P.O.
Saad M.J.A.
Abstract: Introduction: Some inhibitors of tyrosine kinase, as imatinib, erlotinib and sunitinib have antihyperglycemic effects but the mechanisms are not totally clear. Areas covered: It is well established that insulin resistance and beta-cell failure are hallmarks of type 2 diabetes mellitus (DM2). The present review will discuss the molecular mechanisms that account for insulin resistance and beta-cell failure in DM2, and also the effect of tyrosine kinase inhibitors in these processes. Expert opinion: A better understanding of how these drugs improve the two most important mechanisms of DM2 associated with suggestions of clinical studies will lead to improve the treatment of this disease. © 2013 Informa UK, Ltd.
Rights: fechado
Identifier DOI: 10.1517/13543784.2013.802768
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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