Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/89746
Type: Artigo de periódico
Title: The Genome Sequence Of Leishmania (leishmania) Amazonensis: Functional Annotation And Extended Analysis Of Gene Models
Author: Real F.
Vidal R.O.
Carazzolle M.F.
Mondego J.M.C.
Costa G.G.L.
Herai R.H.
Wurtele M.
De Carvalho L.M.
E Ferreira R.C.
Mortara R.A.
Barbieri C.L.
Mieczkowski P.
Da Silveira J.F.
Briones M.R.D.S.
Pereira G.A.G.
Bahia D.
Abstract: We present the sequencing and annotation of the Leishmania (Leishmania) amazonensis genome, an etiological agent of human cutaneous leishmaniasis in the Amazon region of Brazil. L. (L.) amazonensis shares features with Leishmania (L.) mexicana but also exhibits unique characteristics regarding geographical distribution and clinical manifestations of cutaneous lesions (e.g. borderline disseminated cutaneous leishmaniasis). Predicted genes were scored for orthologous gene families and conserved domains in comparison with other human pathogenic Leishmania spp. Carboxypeptidase, aminotransferase, and 3′-nucleotidase genes and ATPase, thioredoxin, and chaperone-related domains were represented more abundantly in L. (L.) amazonensis and L. (L.) mexicana species. Phylogenetic analysis revealed that these two species share groups of amastin surface proteins unique to the genus that could be related to specific features of disease outcomes and host cell interactions. Additionally, we describe a hypothetical hybrid interactome of potentially secreted L. (L.) amazonensis proteins and host proteins under the assumption that parasite factors mimic their mammalian counterparts. The model predicts an interaction between an L. (L.) amazonensis heat-shock protein and mammalian Toll-like receptor 9, which is implicated in important immune responses such as cytokine and nitric oxide production. The analysis presented here represents valuable information for future studies of leishmaniasis pathogenicity and treatment. © The Author 2013.
Editor: 
Rights: aberto
Identifier DOI: 10.1093/dnares/dst031
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84890466311&partnerID=40&md5=6abf5746ec1b22aafde31069c07f56eb
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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