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Type: Artigo de periódico
Title: Does Plasma Hdl-c Concentration Interact With Whole-body Cholesterol Metabolism?
Author: Leanca C.C.
Nunes V.S.
Nakandakare E.R.
de Faria E.C.
Quintao E.C.R.
Abstract: This review examines the interactions between plasma high density lipoprotein (HDL) metabolism and whole-body cholesterol economy. More specifically, this review addresses three questions: 1) does plasma HDL-C concentration correlate with the parameters of whole-body cholesterol metabolism? 2) Do variations in cholesterol metabolism interfere with plasma HDL-C concentrations? 3) Are the markers of cholesterol synthesis and intestinal absorption specifically under the control of plasma HDL? The following answers were provided to each question, respectively: 1) plasma HDL influences whole-body cholesterol synthesis rate but the evidence that HDL modifies the total amount of cholesterol absorbed by the intestine is not clearly supported by present investigations; 2) there are suggestions that changes in whole body cholesterol metabolism rates do not interfere with plasma HDL-C concentrations; 3) markers of cholesterol synthesis and absorption may specifically be controlled by plasma HDL-C concentrations regarding the genetic causes of extremely low HDL-C concentrations, although within the general population plasma HDL-C concentration is likely ascribed to insulin resistance or diabetes mellitus. © 2012 Elsevier B.V.
Rights: fechado
Identifier DOI: 10.1016/j.numecd.2012.12.003
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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