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|Type:||Artigo de periódico|
|Title:||Evaluation Of Boron-doped Diamond Electrode For Simultaneous Voltammetric Determination Of Hydrochlorothiazide And Losartan In Pharmaceutical Formulations|
|Abstract:||A method for the simultaneous determination of hydrochlorothiazide (HCTZ) and losartan (LOS) in pharmaceutical formulations using differential-pulse voltammetry (DPV) was developed. Two very well-resolved and reproducible oxidation peaks of HCTZ and LOS, with separation of 0.23 V, were obtained in Britton-Robinson (BR) buffer (pH 9.5) using an anodically pretreated boron-doped diamond electrode. Under the optimum analytical experimental conditions, the voltammetric method exhibited linear responses for simultaneous determination of HCTZ and LOS in the concentration range 3.0 × 10-6 to 7.4 × 10-5 mol L-1 for both compounds, with detection limits of 1.2 × 10-6 mol L-1 and 9.5 × 10 -7 mol L-1, respectively. The proposed method was successfully applied in the simultaneous determination of LOS and HCTZ content in pharmaceutical formulations, whose accuracy was attested by good agreement of the results (paired t-test at a 95% confidence level) with those obtained using high performance liquid chromatography (HPLC). © 2013 Published by Elsevier B.V.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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