Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/89572
Type: Artigo de periódico
Title: Effect Of Neovestitol-vestitol Containing Brazilian Red Propolis On Accumulation Of Biofilm In Vitro And Development Of Dental Caries In Vivo
Author: Bueno-Silva B.
Koo H.
Falsetta M.L.
Alencar S.M.
Ikegaki M.
Rosalen P.L.
Abstract: The present study examined the influences of the neovestitol-vestitol (NV) containing fraction isolated from Brazilian red propolis on the development of biofilm and expression of virulence factors by Streptococcus mutans using saliva-coated surfaces of hydroxyapatite. In addition, NV was tested in a rodent model of dental caries to assess its potential effectiveness in vivo. Topical applications of NV (800 μg ml-1) significantly impaired the accumulation of biofilms of S. mutans by largely disrupting the synthesis of glucosyltransferase-derived exopolysaccharides and the expression of genes associated with the adaptive stress response, such as copYAZ and sloA. Of even greater impact, NV was as effective as fluoride (positive control) in reducing the development of carious lesions in vivo. NV is a promising natural anti-biofilm agent that targets essential virulence traits in S. mutans, which are associated with the formation of cariogenic biofilm and the subsequent onset of dental caries disease. © 2013 Taylor & Francis.
Editor: 
Rights: fechado
Identifier DOI: 10.1080/08927014.2013.834050
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84885913402&partnerID=40&md5=785f2766c26cc2398e80ec2980345cee
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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