Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/89571
Type: Artigo de periódico
Title: Melatonin And Ethanol Intake Exert Opposite Effects On Circulating Estradiol And Progesterone And Differentially Regulate Sex Steroid Receptors In The Ovaries, Oviducts, And Uteri Of Adult Rats
Author: Chuffa L.G.A.
Seiva F.R.F.
Favaro W.J.
Amorim J.P.A.
Teixeira G.R.
Mendes L.O.
Fioruci-Fontanelli B.A.
Pinheiro P.F.F.
Martinez M.
Martinez F.E.
Abstract: Chronic ethanol intake is associated with sex hormone disturbances, and it is well known that melatonin plays a key role in regulating several reproductive processes. We report the effects of ethanol intake and melatonin treatment (at doses of 100. μg/100. g. BW/day) on sex hormones and steroid receptors in the ovaries, oviducts and uteri of ethanol-preferring rats. After 150 days of treatment, animals were euthanized, and tissue samples were harvested to evaluate androgen, estrogen, progesterone and melatonin receptor subunits (AR, ER-α and ER-β, PRA, PRB and MT1R, respectively). Melatonin decreased estradiol (E2) and increased progesterone (P4) and 6-sulfatoxymelatonin (6-STM), while an ethanol-melatonin combination reduced both P4 and E2. Ovarian AR was not influenced by either treatment, and oviduct AR was reduced after ethanol-melatonin combination. Oviduct ER-α, ER-β and uterine ER-β were down-regulated by either ethanol or melatonin. Conversely, ovarian PRA and PRB were positively regulated by ethanol and ethanol-melatonin combination, whereas PRA was down-regulated in the uterus and oviduct after ethanol consumption. MT1R was increased in ovaries and uteri of melatonin-treated rats. Ethanol and melatonin exert opposite effects on E2 and P4, and they differentially regulate the expression of sex steroid receptors in female reproductive tissues. © 2013 Elsevier Inc.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.reprotox.2013.04.001
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84877322452&partnerID=40&md5=cc32f090ac0cd7f49b56b5a6ff13756a
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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