Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/89565
Type: Artigo de periódico
Title: Nonmotor And Extracerebellar Features In Machado-joseph Disease: A Review
Author: Pedroso J.L.
Franca M.C.
Braga-Neto P.
D'Abreu A.
Saraiva-Pereira M.L.
Saute J.A.
Teive H.A.
Caramelli P.
Jardim L.B.
Lopes-Cendes I.
Barsottini O.G.P.
Abstract: Spinocerebellar ataxia type 3 or Machado-Joseph disease is the most common spinocerebellar ataxia worldwide, and the high frequency of nonmotor manifestations in Machado-Joseph disease demonstrates how variable is the clinical expression of this single genetic entity. Anatomical, physiological, clinical, and functional neuroimaging data reinforce the idea of a degenerative process involving extracerebellar regions of the nervous system in Machado-Joseph disease. Brain imaging and neuropathologic studies have revealed atrophy of the pons, basal ganglia, midbrain, medulla oblongata, multiple cranial nerve nuclei, and thalamus and of the frontal, parietal, temporal, occipital, and limbic lobes. This review provides relevant information about nonmotor manifestations and extracerebellar symptoms in Machado-Joseph disease. The main nonmotor manifestations of Machado-Joseph disease described in previous data and discussed in this article are: sleep disorders, cognitive and affective disturbances, psychiatric symptoms, olfactory dysfunction, peripheral neuropathy, pain, cramps, fatigue, nutritional problems, and dysautonomia. In addition, we conducted a brief discussion of noncerebellar motor manifestations, highlighting movement disorders. © 2013 Movement Disorder Society.
Editor: 
Rights: fechado
Identifier DOI: 10.1002/mds.25513
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84883559735&partnerID=40&md5=97f624d89ee9e8d10c04e5602b75e5db
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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