Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/89543
Type: Artigo de periódico
Title: Characterization Of Semi-solid Self-emulsifying Drug Delivery Systems (sedds) Of Atorvastatin Calcium By Raman Image Spectroscopy And Chemometrics
Author: Breitkreitz M.C.
Sabin G.P.
Polla G.
Poppi R.J.
Abstract: A methodology based on Raman image spectroscopy and chemometrics for homogeneity evaluation of formulations containing atorvastatin calcium in Gelucire® 44/14 is presented. In the first part of the work, formulations with high amounts of Gelucire® 44/14 (80%) and solvents of different polarities (diethylene glycol monoethyl ether, propyleneglycol, propylene glycol monocaprylate and glyceryl mono/dicaprylate/caprate) were prepared for miscibility screening evaluation by classical least squares (CLS). It was observed that Gelucire® 44/14 presented higher affinity for the lipophilic solvents glyceryl mono/dicaprylate/caprate and propylene glycol monocaprylate, whose samples were observed to be homogeneous, and lower affinity for the hydrophilic solvents diethylene glycol monoethyl ether and propyleneglycol, whose samples were heterogeneous. In the second part of the work, the ratio of glyceryl mono/dicaprylate/caprate and Gelucire® 44/14 was determined based on studies in water and allowed the selection of the proportions of these two excipients in the preconcentrate that provided supersaturation of atorvastatin upon dilution. The preconcentrate was then evaluated for homogeneity by partial least squares (PLS) and an excellent miscibility was observed in this proportion as well. Therefore, it was possible to select a formulation that presented simultaneously homogeneous preconcentrate and solubility enhancement in water by Raman image spectroscopy and chemometrics. © 2012 Elsevier B.V.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.jpba.2012.03.054
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84869497263&partnerID=40&md5=c2eab10019bf36528f22759860de36e9
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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