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Type: Artigo de periódico
Title: Early Carotid Atherosclerosis And Hepatic Lipase-514 C/t Polymorphism: A Study In Hyperalphalipoproteinemic Individuals
Author: Santiago F.D.
Schrediber R.
Panzoldo N.B.
Nakamura R.T.
Parra E.S.
Zago V.S.
Bertholo L.
Castanho V.S.
Danelon M.N.
Quintao E.C.R.
De Faria E.C.
Abstract: bjective: Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and has a key role in reverse cholesterol transport and atherosclerosis. The aim of this study was to evaluate the effects of HL -514C/T polymorphism on sub-clinical and established carotid atherosclerotic in hyperalphalipoproteinemic and control individuals. Methods: One hundred and sixty nine asymptomatic individuals (aged 47 ± 16 years), 71 hyperalphalipoproteinemic (Hyper-A, HDL-C ? 68mg/dL) and 98 controls (CTL, HDL-C 68mg/dL) were selected by clinical and laboratory evaluations. Lipids and lipoproteins were measured by enzymatic methods. HL activity was measured in post-heparin plasma by a radiometric assay and HL-514C/T genotypes were analyzed by PCR. Carotid intima-media thickness (cIMT) was measured by Doppler ultrasonography. Results: No differences in HL -514C/T genotype frequencies were observed between the groups. HL -514C/T polymorphism did not contribute to variations in cIMT or atherosclerotic lesion frequencies in Hyper-A and controls. Furthermore, no interactions between HL-514C/T polymorphism and cIMT or atherosclerotic lesions were found.Conclusions: In hyperalphalipoproteinemic individuals the -514C/T polymorphism is not associated with significant variations in HDL-Cholesterol concentrations. Besides, it has no repercussions on carotid atherosclerosis, although hepatic lipase activity is significantly reduced. © 2013 por la Sociedad Argentina de Endocrinologia y Metabolismo.
Rights: aberto
Identifier DOI: 
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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