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Type: Artigo de periódico
Title: Il10 Inversely Correlates With The Percentage Of Cd8+ Cells In Mds Patients
Author: Lopes M.R.
Traina F.
Campos P.D.M.
Pereira J.K.N.
Machado-Neto J.A.
Machado H.D.C.
Gilli S.C.O.
Saad S.T.O.
Favaro P.
Abstract: The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. © 2013 Elsevier Ltd.
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2013.01.019
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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