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|Type:||Artigo de periódico|
|Title:||Il10 Inversely Correlates With The Percentage Of Cd8+ Cells In Mds Patients|
|Abstract:||The role of the immune system in myelodysplastic syndrome (MDS) progression has been widely accepted, although mechanisms underlying this immune dysfunction are not clear. CD4+ and CD8+ lymphocyte profiles in the peripheral blood of MDS patients were evaluated and correlated with clinical characteristics, the expression of FOXP3 and the anti-inflammatory cytokines IL10, TGFβ1 and CTLA4. IL10 expression inversely correlated with the percentage of CD8+ cells and was higher in high-risk MDS. Our findings provide further evidence for the role of T cell-mediated IL10 production in MDS and strengthen the idea of distinct cytokine profiles in low and high-risk MDS. © 2013 Elsevier Ltd.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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