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|Type:||Artigo de periódico|
|Title:||Biocompatibility Study Of Poly(l-acid-lactic)/polycaprolactone Triol Blend [estudo Da Biocompatibilidade Da Blenda De Poli(l-ácido Láctico)/policaprolactona-triol]|
De Barbo M.L.P.
Do Rincon M.C.A.
|Abstract:||Bioabsorbable polymers have been studied for medical applications, especially for orthopedics and traumatology area. Among these promising polymers there is great emphasis on Poly (l-lactic acid), PLLA, due to its high strength and good biocompatibility. In spite of these characteristics, the devices obtained from the PLLA have low elongation and a hydrophobic character, which hamper its use in applications in which the tissue/implant interaction is an important factor. The aim of this work is to obtain PLLA membranes and to improve its properties adding 10% of poly (ε-caprolactone) (PCL-triol), a semicrystalline polymer. For this proposal membranes were implanted in the subcutaneous tissue of Wistar rats and histological analyses of the segments from the implanted areas were performed after 2, 7, 15, 30, 60, 90, 180 days in order to analyze the polymer / tissue interactions. No intense inflammatory reaction was observed along the period of time of the experiment. Fibrous capsules were noted enclosing the area of the implant, in addition to the presence of fibroblasts, fibrocytes and multinucleated giant cells. The PLLA membranes containing PCL-triol showed resistance to the degradation process, even after 180 days.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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