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Type: Artigo de periódico
Title: Extranodal Nasal Nk/t-cell Lymphoma: A Rare Oral Presentation Andfasn,cd44andglut-1expression
Author: Pontes H.A.R.
Pontes F.S.C.
Silva B.S.F.
Fonseca F.P.
de Andrade B.A.B.
Rizo V.H.T.
Romanach M.J.
Leon J.E.
de Almeida O.P.
Abstract: Extranodal natural killer (NK)/T-cell lymphoma is an aggressive malignant tumor with distinctive clinicopathological features, characterized by vascular invasion and destruction, prominent necrosis, cytotoxic lymphocyte phenotype and a strong association with EpsteinBarr virus. Here is reported an extranodal nasal NK/T-cell lymphoma case, involving the maxillary sinus, floor of the orbit, and interestingly extending to the oral cavity through the alveolar bone and buccal mucosa, preserving the palate, leading to a primary misdiagnosis of aggressive periodontal disease. Moreover, this work investigated for the first time the immunohistochemical expression of fatty acid synthase (FASN) and glucose transporter 1 (GLUT-1) proteins in this neoplasia. FASN showed strong cytoplasmatic expression in the neoplastic cells, whereas GLUT-1 and CD44 were negative. These findings suggest that the expression of FASN and the loss of CD44 might be involved in the pathogenesis of the extranodal nasal NK/T-cell lymphoma, and that GLUT-1 may not participate in the survival adaptation of the tumor cells to the hypoxic environment. Further studies with larger series are required to confirm these initial results.
Rights: aberto
Identifier DOI: 10.1590/0103-6440201302202
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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