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Type: Artigo de periódico
Title: Prevalence Of Dyslipidemia In Middle-aged Adults With Nos3 Gene Polymorphism And Low Cardiorespiratory Fitness [prevalência De Dislipidemia Em Adultos De Meia-idade Com Polimorfismo Do Gene Nos3 E Baixa Aptidão Cardiorrespiratória]
Author: Malagrino P.A.
Sponton C.H.G.
Esposti R.D.
Franco-Penteado C.F.
Fernandes R.A.
Bezerra M.A.C.
Albuquerque D.M.
Rodovalho C.M.
Bacci M.
Zanesco A.
Abstract: Objective:To evaluate the influence of the interaction between endothelial nitric oxide synthase gene (NOS3) polymorphisms at positions -786T>C, Glu298Asp and intron 4b/a, and cardiorespiratory fitness on plasma nitrite/nitrate levels, blood pressure, lipid profile, and prevalence of cardiometabolic disorders. Subjects and methods: Ninety-two volunteers were genotyped for NOS3 polymorphisms at positions (-786T>C and Glu298Asp) and (intron 4b/a) and divided according to the genotype: non-polymorphic (NP) and polymorphic (P). After that, they were subdivided according to the cardiorespiratory fitness associated with genotype: high (HNP and HP) and low (LNP and LP). Results: The subjects with polymorphism for the interactions at positions Glu298Asp + intron 4b/a, and Glu298Asp+-786T>C showed the highest values in total cholesterol, as well as dyslipidemia. Conclusion: Our findings show that NOS3 gene polymorphisms at positions -786T>C, Glu298Asp, and intron 4b/a exert negative effects on the lipid profile compared with those who do not carry polymorphisms. © ABE&M todos os direitos reservados.
Rights: aberto
Identifier DOI: 10.1590/S0004-27302013000100005
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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