Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88662
Type: Artigo de periódico
Title: Evaluation Of Cysticercus-specific Igg (total And Subclasses) And Ige Antibody Responses In Cerebrospinal Fluid Samples From Patients With Neurocysticercosis Showing Intrathecal Production Of Specific Igg Antibodies [avaliação Das Respostas De Anticorpos Anti-cisticercos Igg (total E Subclasses) E Ige Em Amostras De Líquido Cefalorraquidiano De Pacientes Com Neurocisticercose Apresentando Produção Intratecal De Anticorpos Específicos Igg]
Author: Suzuki L.A.
Rossi C.L.
Abstract: In the present study, an enzyme-linked immunosorbent assay (ELISA) standardized with vesicular fluid of Taenia solium cysticerci was used to screen for IgG (total and subclasses) and IgE antibodies in cerebrospinal fluid (CSF) samples from patients with neurocysticercosis showing intrathecal production of specific IgG antibodies and patients with other neurological disorders. The following results were obtained: IgG-ELISA: 100% sensitivity (median of the ELISA absorbances (MEA)=1.17) and 100% specificity; IgG1-ELISA: 72.7% sensitivity (MEA=0.49) and 100% specificity; IgG2-ELISA: 81.8% sensitivity (MEA=0.46) and 100% specificity; IgG3-ELISA: 63.6% sensitivity (MEA=0.12) and 100% specificity; IgG4-ELISA: 90.9% sensitivity (MEA=0.85) and 100% specificity; IgE-ELISA 93.8% sensitivity (MEA=0.60) and 100% specificity. There were no significant differences between the sensitivities and specificities in the detection of IgG-ELISA and IgE-ELISA, although in CSF samples from patients with neurocysticercosis the MEA of the IgG-ELISA was significantly higher than that of the IgE-ELISA. The sensitivity and MEA values of the IgG4-ELISA were higher than the corresponding values for the other IgG subclasses. Future studies should address the contribution of IgG4 and IgE antibodies to the physiopathology of neurocysticercosis.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0004-282X2013005000002
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84873686433&partnerID=40&md5=34f726875864803db7220d730cd622ef
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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