Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88617
Type: Artigo de periódico
Title: Comparative Analysis Of Adverse Events Between Infl Iximab And Adalimumab In Crohn's Disease Management: A Brazilian Single-centre Experience [análise Comparativa Dos Eventos Adversos Entre Infliximabe E Adalimumabe No Tratamento Da Doença De Crohn: Experiěncia Em Um Centro Brasileiro]
Author: Kotze P.G.
Akiyoshi F.K.
Luvizotto M.
Olandoski M.
Kotze L.M.S.
Coy C.S.R.
Abstract: Introduction: Data is scarce regarding adverse events (AE) of biological therapy used in the management of Crohn's Disease (CD) among Brazilian patients. Objectives: To analyse AE prevalence and profile in patients with CD treated with Infliximab (IFX) or Adalimumab (ADA) and to verify whether there are differences between the two drugs. Method: Retrospective observational single-centre study of CD patients on biological therapy. Variables analysed: Demographic data, Montreal classifi cation, biological agent administered, treatment duration, presence and type of AE and the need for treatment interruption. Results: Forty-nine patients were analysed, 25 treated with ADA and 24 with IFX. The groups were homogeneous in relation to the variables studied. The average follow-up period for the group treated with ADA was 19.3 months and 21.8 months for the IFX group (p = 0.585). Overall, 40% (n = 10) of patients taking ADA had AE compared with 50% (n = 12) of IFX users (p = 0.571). There was a tendency towards higher incidence of cutaneous and infusion reactions in the IFX group and higher incidence of infections in the ADA treated group, although without significant difference. Conclusions: No difference was found in the AE prevalence and profile between ADA and IFX CD patients in the population studied. © 2013 Elsevier Editora Ltda. All rights reserved.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84880294134&partnerID=40&md5=8d8be15a71f1c9c473b8ddf6958a112e
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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