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Type: Artigo de periódico
Title: Neoadjuvant Therapy And Surgery In Rectal Adenocarcinoma: Analysis Of Patients With Complete Tumor Remission [terapia Neoadjuvante E Cirurgia No Adenocarcinoma Retal: Análise Dos Pacientes Com Remissão Tumoral Completa No Reto]
Author: de Andrade V.A.
Leal R.F.
Fagundes J.J.
Coy C.S.R.
Ayrizono M.L.S.
Abstract: Introduction: the standard treatment for locally advanced extra-peritoneal rectal adenocarcinoma, consists of neoadjuvant treatment with radiotherapy and chemotherapy followed by total mesorectal excision. Objective: evaluate, retrospectively, the patients submitted to neoadjuvant therapy and surgery that presents with total remission of the lesion in the anatomopathological examination. Methods: between 2000 and 2010, 212 patients underwent surgery at the Coloproctology Unit at DMAD at FCM-UNICAMP. They were grouped as: rectosigmoidectomy and colorectal anastomosis (n = 54), rectosigmoidectomy with coloanal anastomosis (n = 41), 114 abdominoperineal resection of the rectum (n = 114) and other (n = 3). Results: thirty (14.2%) patients (mean age 57.6 years; 60% males) showed complete remission of the rectal lesion. 4 (13.3%) had compromised lymph nodes and/or lymphatic invasion At follow-up (mean 51.9 months), 4 (13.3%) presented with local recurrence (one patient) or distant metastases (two patients had liver metastasis, one had liver and lung, and one had bone metastasis). The mean survival was 86.7%. Conclusion: patients with a complete tumor response show ed an increased survival rate, however, the same patients without evidence of residual tumors could develop local recurrence or distant metastases on a later follow-up. © 2013 Elsevier Editora Ltda. All rights reserved.
Rights: aberto
Identifier DOI: 10.1016/j.jcol.2013.08.008
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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