Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88483
Type: Artigo de periódico
Title: Identification Of New Sphingomyelinases D In Pathogenic Fungi And Other Pathogenic Organisms
Author: Dias-Lopes C.
Neshich I.A.P.
Neshich G.
Ortega J.M.
Granier C.
Chavez-Olortegui C.
Molina F.
Felicori L.
Abstract: Sphingomyelinases D (SMases D) or dermonecrotic toxins are well characterized in Loxosceles spider venoms and have been described in some strains of pathogenic microorganisms, such as Corynebacterium sp. After spider bites, the SMase D molecules cause skin necrosis and occasional severe systemic manifestations, such as acute renal failure. In this paper, we identified new SMase D amino acid sequences from various organisms belonging to 24 distinct genera, of which, 19 are new. These SMases D share a conserved active site and a C-terminal motif. We suggest that the C-terminal tail is responsible for stabilizing the entire internal structure of the SMase D Tim barrel and that it can be considered an SMase D hallmark in combination with the amino acid residues from the active site. Most of these enzyme sequences were discovered from fungi and the SMase D activity was experimentally confirmed in the fungus Aspergillus flavus. Because most of these novel SMases D are from organisms that are endowed with pathogenic properties similar to those evoked by these enzymes alone, they might be associated with their pathogenic mechanisms. © 2013 Dias-Lopes et al.
Editor: 
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0079240
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84891380008&partnerID=40&md5=c934cb7e86143ef91920e9fc94a119df
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.