Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88424
Type: Artigo de periódico
Title: Drug Interactions In Female Oncologic Inpatients: Differences Among Databases [interações Medicamentosas Em Mulheres Internadas Com Câncer: Diferenças Entre Bases De Dados]
Author: Moriel P.
Siqueira J.A.
Carnevale R.C.
Rezende Costa C.G.
da Cruz A.A.
da Silva N.M.O.
Bernardes A.C.
Carvalho R.P.
Mazzola P.G.
Abstract: The aim of the present study was to quantify drug interactions in prescriptions for women undergoing supportive therapy in an oncology setting at a women's hospital in Brazil and compare the information provided by different databases regarding these drug interactions. A convenience sample was selected of prescriptions for patients diagnosed with breast or gynecological tumors hospitalized in the clinical oncology and surgery wards from April to June 2009. DRUGDEX/Micromedex (Thomson Micromedex) was the main database used for the identification of drug interactions and was compared with two other databases: Drugs.com and Lexicomp. The search was performed by inputting all drug combinations found in the prescriptions in Micromedex and Drugs.com. All interactions identified and classified by Micromedex and/or Drugs.com as of major severity were then checked in Lexicomp. A total of 152 interactions were identified by Micromedex (61 major, 69 moderate and 22 minor). In Drugs.com, 614 interactions were identified (85 major, 464 moderate and 65 minor). Forty-four were classified as major drug interactions in at least one of the databases: 30 in Micromedex, 26 in Drugs. com and 14 in Lexicomp. The present findings reveal discrepancies among the three databases analyzed. Thus, standardization should be proposed. Moreover, both the pharmacist and multidisciplinary team should perform a critical analysis of prescriptions to promote safe practices in the use of medications and minimize potential complications caused by drug interactions.
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Rights: aberto
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Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84887557037&partnerID=40&md5=87ca180bcafb54f769d3ef58ddfc7ee7
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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