Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88274
Type: Artigo de periódico
Title: Voltammetric Method Optimized By Multi-response Assays For The Simultaneous Measurements Of Uric Acid And Acetaminophen In Urine In The Presence Of Surfactant Using Mwcnt Paste Electrode
Author: Hudari F.F.
Duarte E.H.
Pereira A.C.
Dall'Antonia L.H.
Kubota L.T.
Tarley C.R.T.
Abstract: In the present study, an electroanalytical method for the simultaneous determination of acetaminophen (AC) and uric acid (UA) in urine samples with a carbon nanotube paste electrode (CNTPE) employing a cationic surfactant (cetylpyridinium bromide, CPB) was developed. The optimization of the proposed differential pulse voltammetric method was performed by means of multi-response assays, highly recommended for simultaneous analysis. Under optimized conditions (pH 7.7, phosphate concentration of 0.1 mol L-1, pulse amplitude of 123 mV, modulation time of 5 ms, CPB concentration of 0.30 mmol L-1 and scan rate of 100 mV s-1), a remarkable peak separation of UA and AC at 174 mV was achieved. The linear curves for the simultaneous determination of UA and AC were built in concentration range of 5.0-92.6 μmol L -1 with satisfactory regression of 0.995 for UA and 0.999 for AC. Limits of detection were found to be 0.25 and 0.57 μmol L-1 for UA and AC, respectively, and the precision assessed as relative standard deviation (RSD) for ten determinations was found to be 3.20% and 1.34% for respective concentrations of 10.0 and 72.5 μmol L-1 for UA and 4.3% and 1.6% for AC. The electrochemical sensor with anti-fouling features was successfully applied for the free-interference simultaneous determination of UA and AC in urine samples. © 2013 Elsevier B.V. All rights reserved.
Editor: 
Rights: fechado
Identifier DOI: 10.1016/j.jelechem.2013.01.033
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84876235315&partnerID=40&md5=8a6362ea94092eac9448c46999f8446b
Date Issue: 2013
Appears in Collections:Unicamp - Artigos e Outros Documentos

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