Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88215
Type: Artigo de periódico
Title: Role Of Astrocytes In Thiamine Deficiency
Author: Afadlal S.
Labetoulle R.
Hazell A.S.
Abstract: Thiamine deficiency (TD) is the underlying cause of Wernicke’s encephalopathy (WE), an acute neurological disorder characterized by structural damage to key periventricular structures in the brain. Increasing evidence suggests these focal histological lesions may be representative of a gliopathy in which astrocyte-related changes are a major feature of the disorder. These changes include a loss of the glutamate transporters GLT-1 and GLAST concomitant with elevated interstitial glutamate levels, lowered brain pH associated with increased lactate production, decreased levels of GFAP, reduction in the levels of glutamine synthetase, swelling, alterations in levels of aquaporin-4, and disruption of the blood–brain barrier. This review focusses on how these manifestations contribute to the pathophysiology of TD and possibly WE.
Editor: Springer New York LLC
Rights: fechado
Identifier DOI: 10.1007/s11011-014-9571-y
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84911805787&partnerID=40&md5=14ae2fbbc10660a7941fcadd939cf0b5
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84911805787.pdf313.59 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.