Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88143
Type: Artigo de periódico
Title: Profile Of The Use Of Disease Modifying Drugs In The Brazilian Registry Of Spondyloarthritides [perfil Do Uso De Drogas Modificadoras De Doença No Registro Brasileiro De Espondiloartrites]
Author: Kohem C.
Bortoluzzo A.B.
Goncalves C.
da Silva J.A.B.
Ximenes A.C.
Bertolo M.B.
Ribeiro S.L.E.
Keiserman M.
Menin R.
Skare T.L.
Carneiro S.
Azevedo V.F.
Vieira W.P.
Albuquerque E.N.
Bianchi W.A.
Bonfiglioli R.B.
Campanholo C.
Carvalho H.M.S.
da Costa I.P.
Duarte A.L.B.P.
Leite N.
Lima S.
Meirelles E.S.
Pereira I.A.
Pinheiro M.M.
Polito E.
Resende G.
Rocha F.A.C.
Santiago M.B.
Sauma M.F.L.C.
Valim V.
Sampaio-Barros P.D.
Abstract: Introduction: Few studies have evaluated the profile of use of disease modifying drugs (DMD) in Brazilian patients with spondyloarthritis (SpA). Methods: A common research protocol was applied prospectively in 1505 patients classified as SpA by criteria of the European Spondyloarthropathies Study Group (ESSG), followed at 29 referral centers in Rheumatology in Brazil. Demographic and clinical variables were obtained and evaluated, by analyzing their correlation with the use of DMDs methotrexate (MTX) and sulfasalazine (SSZ). Results: At least one DMD was used by 73.6 % of patients: MTX by 29.2 % and SSZ by 21.7%, while 22.7 % used both drugs. The use of MTX was significantly associated with peripheral involvement, and SSZ was associated with axial involvement, and the two drugs were more administered, separately or in combination, in the mixed involvement (p < 0.001). The use of a DMD was significantly associated with Caucasian ethnicity (MTX, p = 0.014), inflammatory back pain (SSZ, p = 0.002), buttock pain (SSZ, p = 0.030), neck pain (MTX, p = 0.042), arthritis of the lower limbs (MTX, p < 0.001), arthritis of the upper limbs (MTX, p < 0.001), enthesitis (p = 0.007), dactylitis (MTX, p < 0.001), inflammatory bowel disease (SSZ, p < 0.001) and nail involvement (MTX, p < 0.001). Conclusion: The use of at least one DMD was reported by more than 70% of patients in a large cohort of Brazilian patients with SpA, with MTX use more associated with peripheral involvement and the use of SSZ more associated with axial involvement. © 2014 Elsevier Editora Ltda.
Editor: Redprint Editora Ltda
Rights: fechado
Identifier DOI: 10.1016/j.rbr.2013.06.003
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84896532772&partnerID=40&md5=e6641cfe22eaabdea92d666260ba0869
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File Description SizeFormat 
2-s2.0-84896532772.pdf203.04 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.