Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/88024
Type: Artigo de periódico
Title: Hypothalamic Inflammation And The Central Nervous System Control Of Energy Homeostasis
Author: Pimentel G.D.
Ganeshan K.
Carvalheira J.B.C.
Abstract: The control of energy homeostasis relies on robust neuronal circuits that regulate food intake and energy expenditure. Although the physiology of these circuits is well understood, the molecular and cellular response of this program to chronic diseases is still largely unclear. Hypothalamic inflammation has emerged as a major driver of energy homeostasis dysfunction in both obesity and anorexia. Importantly, this inflammation disrupts the action of metabolic signals promoting anabolism or supporting catabolism. In this review, we address the evidence that favors hypothalamic inflammation as a factor that resets energy homeostasis in pathological states.
Editor: Elsevier Ireland Ltd
Rights: fechado
Identifier DOI: 10.1016/j.mce.2014.06.005
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84914163652&partnerID=40&md5=994361ed888f4192af4ec40a56959e57
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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