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Type: Artigo de evento
Title: Layer-by-layer Thin Films Of Alginate/chitosan And Hyaluronic Acid/chitosan With Tunable Thickness And Surface Roughness
Author: Taketa T.B.
Beppu M.M.
Abstract: Layer-by-layer (LbL) is a bottom-up technique used for construction of films with selfassembly and self-organizing properties. In most cases, the fundamental driving force for the formation of these films is originated from the electrostatic interaction between oppositely charged species. The charged segments of polyelectrolytes behave as small building units and their orientation and position can be designed to target structures of great complexity. Furthermore, the technique enables the use of various materials, including natural polymers. In this work, we chose the cationic biopolymer chitosan (CHI) and the negative polyelectrolytes sodium alginate (ALG) and hyaluronic acid (HA). The aim of this study was to evaluate the effect of ionic strength (0 versus 200 mM) and pH (3 versus 5) on ALG/CHI and HA/CHI nanostructured multilayered thin films properties. From profilometry and atomic force microscopy (AFM) analyses, changes in thickness and roughness of the coatings were monitored. The presence of salt in polyelectrolyte solutions induced the polymer chains to adopt conformations with more loops and tails and this arrangement in solution was transmitted to films, resulting in rougher surfaces. Furthermore, the film thickness can be precisely controlled by adjusting the pH of the polyelectrolyte solution. The variation of these parameters shows that it is possible to molecularly control chemical and structural properties of nanostructured coatings, thus opening up new possibilities of application (e.g. cell adhesion). © (2014) Trans Tech Publications, Switzerland.
Editor: Trans Tech Publications Ltd
Rights: fechado
Identifier DOI: 
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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