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Type: Artigo de periódico
Title: Antifungal And Cytotoxic 2-acylcyclohexane-1,3-diones From Peperomia Alata And P. Trineura
Author: Ferreira E.A.
Reigada J.B.
Correia M.V.
Young M.C.M.
Guimaraes E.F.
Franchi G.C.
Nowill A.E.
Lago J.H.G.
Yamaguchi L.F.
Kato M.J.
Abstract: Bioactivity-guided fractionation of the separate CH2Cl 2 extracts from the aerial parts of Peperomia alata and P. trineura yielded seven polyketides: alatanone A [3-hydroxy-2-(5′-phenylpent- 4′E-enoyl)cyclohex-2-en-1-one, 1a] and alatanone B [3-hydroxy-2-(3′- phenyl-6′-methylenedioxypropanoyl)cyclohex-2-en-1-one, 2a] from P. alata and trineurone A [3-hydroxy-2-(11′-phenylundec-10′E-enoyl)cyclohex- 2-en-1-one, 1b], trineurone B [3-hydroxy-2-(15′-phenyl-18′- methylenedioxypentadecanoyl)cyclohex-2-en-1-one, 2b], trineurone C [3-hydroxy-2-(17′-phenyl-20′-methylenedioxyheptadecanoyl) cyclohex-2-en-1-one, 2c], trineurone D [3-hydroxy-2-(hexadec-10′Z-enoyl) cyclohex-2-en-1-one, 3a], and trineurone E [(6R)-(+)-3,6-dihydroxy-2-(hexadec- 10′Z-enoyl)cyclohex-2-en-1-one, 3b] from P. trineura. The isolated compounds were evaluated for antifungal activity against Cladosporium cladosporioides and C. sphaeospermum and for cytotoxicity against the K562 and Nalm-6 leukemia cell lines. © 2014 The American Chemical Society and American Society of Pharmacognosy.
Editor: American Chemical Society
Rights: fechado
Identifier DOI: 10.1021/np500130x
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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