Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87822
Type: Artigo de periódico
Title: Evaluation Of Soft-tissue Lesions With 18f-fdg Pet/ct: Initial Results Of A Prospective Trial
Author: Leal A.L.
Etchebehere M.
Santos A.O.
Kalaf G.
Pacheco E.B.
Amstalden E.M.
Etchebehere E.C.
Abstract: Purpose of the report: Although MRI is utilized for planning the resection of soft-tissue tumors, it is not always capable of differentiating benign from malignant lesions. The risk of local recurrence of soft-tissue sarcomas is increased when biopsies are performed before resection and by inadequate resections. PET associated with computed tomography using fluorodeoxyglucose labeled with fluorine-18 (18F-FDG PET/CT) may help differentiate between benign and malignant tumors, thus avoiding inadequate resections and making prior biopsies unnecessary. The purpose of this study was to evaluate the usefulness of 18F-FDG PET/CT in differentiating benign from malignant solid soft-tissue lesions. Materials and methods: Patients with solid lesions of the limbs or abdominal wall detected by MRI were submitted to 18F-FDG PET/CT. The maximum standardized uptake value (SUV max) cutoff was determined to differentiate malignant from benign tumors. Regardless of the 18F-FDG PET/CT results all patients underwent biopsy and surgery. Results: MRI was performed in 54 patients, and 10 patients were excluded because of purely lipomatose or cystic lesions. 18F-FDG PET/CT was performed in the remaining 44 patients. Histopathology revealed 26 (59%) benign and 18 (41%) malignant soft-tissue lesions. A significant difference in SUVmax was observed between benign and malignant soft-tissue lesions. The SUVmax cutoff of 3.0 differentiated malignant from benign lesions with 100% sensitivity, 83.3% specificity, 89.6% accuracy, 78.3% positive predictive value, and 100% negative predictive value. Conclusion: 18F-FDG PET/CT seems to be able to differentiate benign from malignant soft-tissue lesions with good accuracy and very high negative predictive value. Incorporating 18F-FDG PET/CT into the diagnostic algorithm of these patients may prevent inadequate resections and unnecessary biopsies. © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Editor: 
Rights: fechado
Identifier DOI: 10.1097/MNM.0000000000000041
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84893808844&partnerID=40&md5=316de68fcf6121cd240a6c6144712f06
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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