Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87692
Type: Artigo de periódico
Title: Anti-hemorrhagic Effect Of Hydro-alcoholic Extract Of The Leaves Of Mikania Glomerata In Lesions Induced By Bothrops Jararaca Venom In Rats
Author: Mourao V.B.
Giraldi G.M.
Neves L.M.G.
de Gaspari de Gaspi F.O.
Rodrigues R.A.F.
Alves A.A.
Esquisatto M.A.M.
Mazzi M.V.
Mendonca F.A.S.
dos Santos G.M.T.
Abstract: Purpose: To investigate the effects of hydroalcoholic leaf extract of Mikania glomerata Spreng (Asteraceae) on the activity of Bothrops jararaca snake venom in Wistar rats. Methods: Fifty four rats Wistar were divided into six groups of nine animals in each: control treated with saline; control treated with B. jararaca venom; control treated with M. glomerata extract; B. jararaca venom incubated with M. glomerata extract at proportions of 1:1, 1:2, and 1:4. Results: Histopathological and morphometric analysis showed that intradermal administration of snake venom incubated with the hydroalcoholic extract at proportions of 1:1, 1:2 and 1:4 promoted a significant reduction in the number of inflammatory cells and a marked decrease in edema after the third hour. There was also a significant reduction in the intensity of the hemorrhagic halo in animals receiving the snake venom incubated with the extract, with the observation of a progressive and parallel inhibition with increasing proportion of M. glomerata. Conclusion: The Mikania glomerata hydroalcoholic extract exerted effective anti-inflammatory and antihemorrhagic activity against the effects induced by Bothrops jararaca snake venom.
Editor: 
Rights: aberto
Identifier DOI: 10.1590/S0102-86502014000100005
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84892605591&partnerID=40&md5=0424fd8da785b7fc5eb33cb0a6e9c192
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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