Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87691
Type: Artigo de periódico
Title: Comparative Study Of Tissue Reactivity To N-butyl-2-cyanoacrylate And Nylon Monofilament Thread On Pericranium-cutaneous Flaps In Rats
Author: Cavazana W.C.
Ioshii S.O.
Cuman R.K.N.
Passeri L.A.
Abstract: PURPOSE: To study the repair of pericranium-cutaneous flaps fixed with suture anchored in a skull bone tunnel or N-butyl-2-cyanoacrylate adhesive in Wistar rats with emphasis on the cellular inflammatory response and the production of types I and III collagen. METHODS: The operated region in the cephalic region of Wistar rats was removed minutes before euthanasia, fixed in formalin, and subjected to histological preparation. Slides were stained with hematoxylin-eosin and Picrosirius. Standardized counts of polymorphonuclear and mononuclear cells, fibroblasts, and macrophages were performed, and the percentages of types I and III collagen were determined. Data collection occurred on days 3, 7, 14, 21, and 45 postoperatively. A value of p<0.05 was considered statistically significant. RESULTS: Quantitative analysis of the data showed more fibroblasts in the surgical adhesive group than in the nylon monofilament thread groups (p=0.0211). Qualitative analysis showed higher reactivity in the adhesive group, with a predominance of polymorphonuclear cells from days 3-45 and macrophages from days 3-7. The amount of type I collagen exceeded 80% in the treated and control groups at the end of the experiment. CONCLUSIONS: Subperiosteal detachment triggers a cellular inflammatory response that is amplified using soft tissue fixation methods. The adhesive n-butyl-2-cyanoacrylate was more reactive than the nylon monofilament thread anchored in the skull bone tunnel.
Editor: Sociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia
Rights: aberto
Identifier DOI: 10.1590/S0102-86502014000400007
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84898864919&partnerID=40&md5=f008aee0544fea3898be3fc348bb556f
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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