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dc.typeArtigo de periódicopt_BR
dc.titleTobacco Experimental Model To Induce Urinary Bladder Neoplasms [modelo Experimental De Tabagismo Para Indução De Neoplasia Da Bexiga Urinária]pt_BR
dc.contributor.authorColli Neto J.A.pt_BR
dc.contributor.authorZen Junior J.H.pt_BR
dc.contributor.authorDel Negro A.pt_BR
dc.contributor.authorAndreollo N.A.pt_BR
dc.contributor.authorAraujo M.R.pt_BR
dc.contributor.authorTincani A.J.pt_BR
unicamp.authorColli Neto, J.A., School of Medicine, UNICAMP, Brazilpt_BR
unicamp.authorZen Júnior, J.H., School of Medicine, UNICAMP, Brazilpt_BR
unicamp.authorDel Negro, A., Department of Surgery, UNICAMP, Brazilpt_BR
unicamp.authorAndreollo, N.A., Department of Surgery, UNICAMP, Brazilpt_BR
unicamp.authorAraujo, M.R., Center for Experimental Medicine and Surgery, UNICAMP, Brazilpt_BR
unicamp.authorTincani, A.J., Department of Surgery, UNICAMP, Brazilpt_BR
dc.description.abstractObjective: To develop an experimental model of exposure to tobacco burning (cigarette) products to assess the effects of its chronic use in relation to cancers of the bladder. Methods: The animals were chronically exposed to the burning tobacco products in a semi-open chamber to simulate smoking. Thirty young Wistar rats were divided into two groups: one with 20 animals simulating smoking for six months, and ten not exposed control animals for the same period. After exposure by inhalation of cigarette smoke, animals were euthanized and subjected to histopathological study of the bladder wall. Results: No tumor was found but mild and non significant alterations. The studies of hemo-oximetry (carboxyhemoglobin and methemoglobin) and the concentration of carbon dioxide (CO2) confirm that the animals were exposed to high concentrations of tobacco smoke and its derivatives. Conclusion: No bladder mucosal neoplasia was found in the pathological study of animals. The developed experimental models were highly efficient, practical and easy to use and can be used in other similar studies to determine the harmful effects caused by smoking.en
dc.relation.ispartofRevista do Colegio Brasileiro de Cirurgioespt_BR
dc.publisherColegio Brasileiro de Cirurgioespt_BR
dc.identifier.citationRevista Do Colegio Brasileiro De Cirurgioes. Colegio Brasileiro De Cirurgioes, v. 41, n. 1, p. 56 - 59, 2014.pt_BR
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