Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87612
Type: Artigo de periódico
Title: Tobacco Experimental Model To Induce Urinary Bladder Neoplasms [modelo Experimental De Tabagismo Para Indução De Neoplasia Da Bexiga Urinária]
Author: Colli Neto J.A.
Zen Junior J.H.
Del Negro A.
Andreollo N.A.
Araujo M.R.
Tincani A.J.
Abstract: Objective: To develop an experimental model of exposure to tobacco burning (cigarette) products to assess the effects of its chronic use in relation to cancers of the bladder. Methods: The animals were chronically exposed to the burning tobacco products in a semi-open chamber to simulate smoking. Thirty young Wistar rats were divided into two groups: one with 20 animals simulating smoking for six months, and ten not exposed control animals for the same period. After exposure by inhalation of cigarette smoke, animals were euthanized and subjected to histopathological study of the bladder wall. Results: No tumor was found but mild and non significant alterations. The studies of hemo-oximetry (carboxyhemoglobin and methemoglobin) and the concentration of carbon dioxide (CO2) confirm that the animals were exposed to high concentrations of tobacco smoke and its derivatives. Conclusion: No bladder mucosal neoplasia was found in the pathological study of animals. The developed experimental models were highly efficient, practical and easy to use and can be used in other similar studies to determine the harmful effects caused by smoking.
Editor: Colegio Brasileiro de Cirurgioes
Rights: aberto
Identifier DOI: 10.1590/S0100-69912014000100011
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84899629889&partnerID=40&md5=b713c942cc9d69e3d13bdc644591268f
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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