Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87587
Type: Artigo de periódico
Title: State Of The Art Two-dimensional Liquid Chromatography: Fundamental Concepts, Instrumentation, And Applications [o Estado Da Arte Da Cromatografia Líquida Bidimensional: Conceitos Fundamentais, Instrumentac¸ão E Aplicac¸ões]
Author: Mogollon N.G.S.
De Lima P.F.
Gama M.R.
Furlan M.F.
Braga S.C.G.N.
Prata P.S.
Jardim I.C.S.F.
Augusto F.
Abstract: The constant evolution of science and the growing demand for new technologies have led to new techniques in instrumentation that can improve detection, separation, resolution, and peak capacity. Comprehensive two-dimensional liquid chromatography (LCxLC) is presented as a powerful tool in complex sample analyses. During an analysis, a sample is subjected to two independent separation mechanisms that are combined, resulting in increased resolving power. For appropriate application of LCxLC, understanding the influence of parameters that require optimization is necessary. The main purpose of optimization is to predict the combination of stationary phases, separation conditions, and instrumental requirements to obtain the best separation performance. This review discusses theoretical, intrumental, and chemometric aspects of LCxLC and focuses on its applications in foods. It aims to provide a clear understanding of the aspects that can be used as strategies in the optimization of this analytical method.
Editor: Sociedade Brasileira de Quimica
Rights: aberto
Identifier DOI: 10.5935/0100-4042.20140261
Address: http://www.scopus.com/inward/record.url?eid=2-s2.0-84916234741&partnerID=40&md5=dafa971556028f907b71d088c9a910e9
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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