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Type: Artigo de periódico
Title: Voltammetric Determination Of Amitriptyline In Pharmaceutical Formulation With Boron-doped Diamond Electrode Exploiting Measures In Acid Medium [determinação Voltamétrica De Amitriptilina Em Formulações Farmacêuticas Com Eletrodo De Diamante Dopado Com Boro Explorando Medidas Em Meio ácido]
Author: Duarte E.H.
Gorla F.A.
Sartoria E.R.
Tarley C.R.T.
Abstract: A simple and reliable voltammetric method is presented for the determination of amitriptyline using a boron-doped diamond electrode in 0.1 mol L-1 sulfuric acid solution as the support electrolyte. Under optimized differential pulse voltammetry conditions (modulation time 5 ms, scan rate 70 mV s-1, and pulse amplitude 120 mV), the electrode provides linear responses to amitriptyline in the concentration range 1.05 to 92.60 μmol L-1 and at a detection limit of 0.52 μmol L-1. The proposed method was successfully applied in pharmaceutical formulations, with results similar to those obtained using UV-vis spectrophotometric method as reference (at 95% confidence level), as recommended by the Brazilian Pharmacopoeia.
Editor: Sociedade Brasileira de Quimica
Rights: aberto
Identifier DOI: 10.5935/0100-4042.20140225
Date Issue: 2014
Appears in Collections:Unicamp - Artigos e Outros Documentos

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