Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/87502
Type: Artigo
Title: The intrahippocampal infusion of crotamine from Crotalus durissus terrificus venom enhances memory persistence in rats
Author: Vargas, Liane S.
Lara, Marcus V. S.
Gonçalves, Rithiele
Mandredini, Vanusa
Ponce-Soto, Luis Alberto
Marangoni, Sergio
Dal Belo, Cháriston A.
Mello-Carpes, Pâmela B.
Abstract: Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory. © 2014 Elsevier Inc. All rights reserved.
Previous research has shown that crotamine, a toxin isolated from the venom of Crotalus durissus terrificus, induces the release of acetylcholine and dopamine in the central nervous system of rats. Particularly, these neurotransmitters are important modulators of memory processes. Therefore, in this study we investigated the effects of crotamine infusion on persistence of memory in rats. We verified that the intrahippocampal infusion of crotamine (1 μg/μl; 1 μl/side) improved the persistence of object recognition and aversive memory. By other side, the intrahippocampal infusion of the toxin did not alter locomotor and exploratory activities, anxiety or pain threshold. These results demonstrate a future prospect of using crotamine as potential pharmacological tool to treat diseases involving memory impairment, although it is still necessary more researches to better elucidate the crotamine effects on hippocampus and memory
Subject: Venenos de serpentes
Toxinas
Memoria animal
Estimulos aversivos
Rato
Country: Reino Unido
Editor: Elsevier
Citation: Toxicon. Elsevier Ltd, v. 85, n. , p. 52 - 58, 2014.
Rights: fechado
Identifier DOI: 10.1016/j.toxicon.2014.04.017
Address: https://www.sciencedirect.com/science/article/pii/S0041010114001263
Date Issue: 2014
Appears in Collections:IB - Artigos e Outros Documentos

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